Benzodiazepine Hypnotics: Kinetic and Therapeutic Options
نویسندگان
چکیده
منابع مشابه
Benzodiazepine hypnotics increase heart rate during sleep.
The cardiovascular effects of benzodiazepines administered intravenously as preoperative sedatives have received considerable study, but sleep laboratory research on benzodiazepines administered orally as hypnotics has not focused on assessment of cardiovascular changes. Analysis of heart rate (HR) data collected in sleep laboratory studies on the effects of 0.5 mg of triazolam (Halcion) and 30...
متن کاملBenzodiazepine hypnotics remain effective for 24 weeks.
Ninety-seven poor sleepers aged 40-68 years took capsules nightly for 32 weeks and made daily subjective ratings. The benzodiazepine hypnotics lormetazepam 2 mg and nitrazepam 5 mg appeared still to improve sleep after 24 weeks of intake when compared with continuous placebo intake. The sustained effectiveness was most evident in a significant shortening of the time taken to fall asleep in pati...
متن کاملResidual effects of benzodiazepine and non-benzodiazepine hypnotics on diurnal attention in a reaction time task
xiety and sleep disorders. However, they have frequently negative residual effects on tasks requering spatial and visual abilities and sustained attention. Moreover, benzodiazepines may provoke an impairment of motor responses, also altering the capacity to estimate the time (Bensimon et al., 1990; Bocca et al, 1999; Myzuki et al., 1987; Sierra et al., 1993). Consequently, the level of attentio...
متن کاملResidual Effects of Short Half-life Non-benzodiazepine Hypnotics
Background Since their introduction at the beginning of the 1990s the short half-life nonbenzodiazepine hypnotics, zolpidem and zopiclone, rapidly were among the most frequently prescribed hypnotics. Surveys showed that around 1996 the most frequently prescribed hypnotic in the US was zolpidem, while zolpidem and zopiclone were among the five most frequently used hypnotics in Europe [1, 2]. The...
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Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system associated to myelin loss and neurodegeneration. Clinically patients suffer from diverse symptoms and face the risk to become wheelchair-bound. At the moment MS is incurable, thus there is an unmet need for therapeutic options.
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ژورنال
عنوان ژورنال: Sleep
سال: 1982
ISSN: 0161-8105,1550-9109
DOI: 10.1093/sleep/5.suppl_1.s18